When you're trying to find a major landmark in Venice, it's often easiest to put your Venice street map away and follow the crowd to destinations such as:
San Marco (the Piazza, the Basilica, the Campanile, and the Doge's Palace)
Accademia (the Accademia Bridge, the Accademia art gallery)
Rialto (Rialto Bridge, fish market, and food market)
Ferrovia (railroad station)
Piazzale Roma (cars, buses, parking, cruise shuttle buses, and People Mover)
Along the way, you'll see signs with names of streets and campi, which often are in Venetian dialect instead of standard Italian.
But the most important signs, if you aren't familiar with the city's geography, are the signs--both official and unofficial--that will guide you to where you're going. Here are examples of the signs on buildings or above passages that mark some of the major pedestrian routes in Venice's historic center:
For more advice on getting around without getting lost, see "Walking in Venice: Finding your way with maps, directions, and street signs" at Veniceforvisitors.com.